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6 , 7 Liquid chromatographic techniques for the identification of phenolic content have been described. 14 Uses and Pharmacology Anti-inflammatory action Earlier studies attributed anti-inflammatory activity to the saponin content of the plant. 12 Antioxidant activity of the phenols in yucca may also be responsible for an anti-inflammatory effect because they inhibit inducible nitric oxide synthetase (iNOS), as well as influence arachidonate metabolism and inhibit COX-1 and COX-2 enzymes. 11 , 12 Despite the addition of yucca extracts to equine joint supplement preparations and their use in human arthritis treatment based on a few poor-quality studies from the 1970s, no clinical trials exist to support this use. 12 , 15 , 16 Antimicrobial activity Yucca leaf protein.