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What does XRCC1 stand for?

XRCC1 stands for X-ray repair cross-complementing gene 1


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Nucleotide excision repair (NER) repairs damage to a nucleotide strand containing at least 2 bases and creating a structural distortion of the DNA. NER acts to repair single strand breaks in addition to serial damage from exogenous sources such as bulky DNA adducts and UV radiation. 26 The same pathway may be used to repair damage from oxidative stress. 27 Over 20 proteins are involved in the NER pathway in mammalian cells, including XPA, XPC-hHR23B, replication protein A (RPA), transcription factor TFIIH, XPB and XPD DNA helicases, ERCC1-XPF and XPG, Pold, Pole, PCNA, and replication factor C. 28 Overexpression of the excision repair cross-complementing (ERCC1) gene.