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Angiotensin-converting enzyme (EC 3. 4. 15. 1), or "ACE" indirectly increases blood pressure by causing blood vessels to constrict. It does that by converting angiotensin I to angiotensin II, which constricts the vessels. For this reason, drugs known as ACE inhibitors are used to lower blood pressure.
Stromal macrophages from benzene-treated mice were capable of the transcription of the IL-la gene and the translation of the message but showed an inability to process the 34-kDa pre-IL-1a precursor to the 17-kDa biologically active cytokine. Treatment of normal murine stromal macrophages in culture with hydroquinone (HQ) also showed an inhibition in processing of pre-IL-1 a. Hydroquinone is oxidized by a peroxidasemediated reaction in the stromal macrophage to p-benzoquinone, which interacts with the sulfhydryl (SH) groups of proteins and was shown to completely inhibit the activity of calpain, the SH-dependent protease that cleaves pre-IL-1 a. In a similar manner, HQ, via peroxidase oxidation to p-benzoquinone, was capable of preventing the IL-1,B autocrine stimulation of growth of human B1 myeloid tumor cells by preventing the processing of pre-IL-1f to mature cytokine. Benzoquinone was also shown to completely inhibit the ability of the SH-dependent IL-1lB converting enzyme.
Protein also known as: Dipeptidyl carboxypeptidase I; CD antigen CD143. Cleaved into: Angiotensin-converting enzyme.
Angiotensin I converting enzyme 2 (ACE 2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9], or the conversion of angiotensin II to angiotensin 1-7.  ACE 2 has direct effects on cardiac functiona, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.
[The influence of single nucleotide polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme on the course of pregnancy complicated by type 1 diabetes]. Wender-Ozegowska E, Iciek R, Seremak-Mrozikiewicz A, et al. Ginekol. Pol.
Catt KJ, Keiser HR: The effect of converting enzyme inhibition with SQ20. 881 on plasma and urinary kinins, prostaglandin E, and angiotensin II in hypertensive man. Hypertension 1 - JM, Horwitz, et al.
The angiotensin-converting enzyme (ACE) inhibitors are a widely used class of antihypertensive medications that act by blocking the conversion of angiotensin I to angiotensin II, thus inhibiting an intermediate step in the renin-angiotensin pathway. The ACE inhibitors are rare causes of clinically apparent liver injury. The ACE inhibitors act by blocking the conversion of angiotensin I to angiotensin II, the active peptide that causes the vasoconstriction and sodium retention induced by activation of the renin-angiotensin pathway.