What does RAGs stand for?
RAGs stands for V(D)J-recombination-activating genes
This definition appears rarely
See other definitions of RAGs
Samples in periodicals archive:
Recombination Activating Gene (RAG): A RAG is a gene that codes for a RAG protein (the names of genes are italicized, and the corresponding proteins are not; sometimes PDF and HTML documents will be missing this formatting however). RAG proteins have the ability to recognize specific DNA sequences at two locations called Recombination Signal Sequences (RSSs), bring the pieces together, and cut the DNA at the RSS sites.
Pillars Article: The V(D)J Recombination Activating Gene, RAG-1. Cell 1989. 59: 1035–1048.
RAG MiceRAG mice are deficient in the recombination activating gene (RAG). Two proteins, RAG1 and RAG2, are synergistically responsible for activation of V(D)J recombination during T cell development [74, 75]. When either of these proteins is inactivated, the mice are deficient in both B and T cells, similar to SCID mice [76, 77]. These mice also have an inflammatory response and NK cell activity.
David G. Schatz and Marjorie Oettinger, as students in Baltimore's research group in 1988 and 1989, identified the protein pair that rearranges immunoglobulin genes, the recombination activating genes RAG-1 and RAG-2.  This was a key discovery in determining how the immune system can have specificity for a given molecule out of many possibilities, and was considered by Baltimore as of 2005 to be "our most significant discovery in immunology".