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What does T/B stand for?

T/B stands for Target-to-background


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All three compounds remained intact after 120 min incubation with mouse serum. They all had a rapid and relatively high tracer uptake in U87MG tumors with good target-to-background ratios. Compared with the other two tracers, (18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2 had the highest tumor uptake and the lowest accumulation in the liver. The integrin receptor specificity was confirmed by co-injection of unlabeled dimeric RGD peptide.
¦ Tc-99m has more optimal energy ¦ Higher injected dose means more photons and better counting statistics ¦ Higher target to background.
Also, some tumors may actually have an SUV of less than 2. 5, while other benign processes such as active inflammation may have an SUV above 2. 5. So the key is not to rely on an absolute number, but to identify what is abnormal for the particular patient in his or her particular context and to use all the relevant clinical and imaging information on hand to provide the proper information to the patient and his or her provider. A high target-to-background.
We were able to get as close as 10cm, which in turn helps get some separation from target to background.
Imaging is typically performed 60 minutes after injection of radiotracer to allow for sufficient blood pool clearance to improve target-to-background ratio. Normal physiologic uptake is seen in the brain and myocardium and to a lesser extent in the liver, spleen, bone marrow, GI tract, renal cortex, testes and skeletal musculature. Mycocardial uptake is variable in fasting patients but often intense in nonfasting individuals.