Through the use of synthetic T4-containing peptides; the T4-containing Tg sequence described here is implicated as a pathogenic epitope in murine thyroid...
sensitized spleen cells activated in vitro with MTg can induce two histologically distinct forms of experimental autoimmune thyroiditi; (T4)-containing peptide.
The combined action of two thyroidal proteases releases T4 from the dominant hormone-forming site of thyroglobulin; producing small T4-containing peptides.