This definition appears rarely
See other definitions of SMRT
Samples in periodicals archive:
However, the role of another class of nuclear cofactors, the nuclear receptor corepressors, in modulating PPARgamma transcriptional activity is less clear. Such corepressors include the nuclear receptor corepressor (NCoR) and the silencing mediator of retinoid and thyroid hormone receptors (SMRT). Our data suggest that PPARgamma recruits SMRT and NCoR in the absence of ligand and that these corepressors are capable of down-regulating PPARgamma-mediated transcriptional activity.
The RXRs have been shown to enhance the DNA-binding activity of RARs and the thyroid hormone receptors (TRs). The RXRs represent a class of receptors that bind the retinoid 9-cis-retinoic acid. There are three isotypes of the RXRs: RXRα, RXRβ, and RXRγ and each isotype is composed of several isoforms. The RXRs serve as obligatory heterodimeric partners for numerous members of the nuclear receptor family including PPARs, LXRs, and FXRs (see below and the Signal Transduction page). In the absence of a heterodimeric binding partner the RXRs are bound to hormone response elements (HREs) in DNA and are complexed with co-repressor proteins that include a histone deacetylase (HDAC) and silencing mediator of retinoid and thyroid.
(2006) reported a newborn Turkish male, the child of nonconsanguineous parents, with severe but predominantly pituitary thyroid hormone resistance (145650) who presented at 6 days of age with respiratory distress, tachycardia, diaphoresis, and a thyroid gland 4 times normal size. The authors hypothesized that the RTH was due to reduced ligand binding and/or abnormal interaction with nuclear cofactors. Sequencing of the THRB gene demonstrated a de novo heterozygous mutation, 1590_1591insT, resulting in a frameshift producing a mutant THR-beta with a 28-amino acid nonsense sequence and 2-amino acid carboxyl-terminal extension. The mutant TR-beta had impaired ability to recruit nuclear receptor corepressor (NCOR1; 600849) but intact association with silencing mediator of retinoid and thyroid.
The PPAR: RXR heterodimer exists in both an active and inactive state. When inactive, it is bound to corepressors such as the NCOR (Nuclear Receptor Corepressor) or the SMRT (Silencing Mediator For Retinoid and Thyroid Hormone Receptor). In the presence of ligand for either PPAR or RXR, the corepressors dissociate so that the ligand can bind and activate co-activators, such as SRC1 (Steroid Receptor Coactivator1), CBP/p300 (CREB-Binding Protein), the Tuberous Sclerosis Gene-2 product, the PPAR binding protein, P-GammaC1, P-GammaC2 (PPAR-Gamma Coactivator 1 and 2), and Ara70 (Ref.