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Figure 1. Fusion proteins containing glutathione S-transferase and galectin-3 sequences of varying lengths
Matricellular proteins have been implicated in cell adhesion, migration and proliferation. Here we investigated the role of thematricellular protein galectin-1 (Gal-1), a b-galactoside-binding lectin, in SMC proliferation in atheroma and DNA synthesis in cellculture. Methods: Protein expression was visualised by tissue section immunostaining. RNA expression was analysed using Northern blotanalysis. DNA synthesis of human vascular SMCs was determined bytransferase–galectin-1 fusion protein.