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What does PSD stand for?

PSD stands for Post Synaptic Density


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MA1-046 detects post synaptic density 95 (PSD-95) from human, rat, xenopus laevis and mouse tissues. MA1-046 has been successfully used in Western blot, immunofluorescence, immunocytochemistry, immunohistochemistry, flow cytometry and immunoprecipitation procedures. By Western blot, this antibody detects an ~95 kDa protein representing PSD-95 from rat brain extracts. Immunofluorescence staining of PSD-95 in rat hippocampal cells with MA1-046 yields a staining pattern coincident with NMDA receptor.
Continuous gradients allow for the separation of proteins into multiple fractions; this can be particularly useful to demonstrate the co-localization of proteins within a given fraction8. However, the preparation of continuous gradients is more laborious and is unnecessary for many applications. Discontinuous gradients are comparatively easier to prepare and can be used to separate proteins into a few, generally-defined fractions. Discontinuous gradients that are composed of three sucrose layers of increasing molarity have been widely used to isolate proteins associated with the synaptic plasma membrane (SPM). This synaptic plasma membrane fraction can be further processed to the post-synaptic density.
Significant work has focused on protein synthesis in the post-synaptic density11-13, but little work has been done to study protein synthesis in the presynaptic compartments. However, there is evidence that protein synthesis occurs in the presynaptic terminals. 7-10 As can be seen in the electron micrograph of the SNs, pre- and postsynaptic attachments exists in the SN preparation making them an ideal system for future study of translational activity in both compartments.
With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. [1] PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density.