What does -IR stand for?
-IR stands for PSA-NCAM-immunoreactivity
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Studies in the fetal brain focus on the localization of PSA-NCAM in discrete forebrain regions and on its role in developmental processes, such as neuronal migration and transitory axonal projections , and onset of myelination . In the adult, evidence for the persistence of PSA-NCAM is restricted to the cerebral cortex [29-31] and peripheral nerve , where altered expression of the molecule has also been described in a number of neuropathological conditions [32-38]. In order to explore further the existence of neurons expressing the molecule in the human nervous system, thus providing potential for its dynamic changes and plasticity in response to environmental contests, we analysed whether PSA-NCAM occurs in the human primary sensory neurons, namely those of the trigeminal ganglion (TG), and in the morphofunctional heterogeneous populations of the brainstem. The study has been carried out by immunohistochemistry on normal tissue and conveys data on the occurrence of PSA-NCAM immunoreactivity.