This definition appears rarely
Samples in periodicals archive:
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. Liu L, Watanabe K, Fang Q, et al. Chem. Res. Toxicol.
Although alkylating mutagens preferentially modify the guanine base at the N7 position, O6-alkyl-guanine is a major carcinogenic lesion in DNA. This DNA adduct is removed by the repair protein O6-alkylguanine DNA alkyltransferase through an SN2 mechanism. This protein is not a true enzyme since it removes the alkyl group from the lesion in a stoichiometric reaction and the active enzyme is not regenerated after it is alkylated (referred to as suicide enzyme).
Gerson SL, Phillips W, Kastan M, Dumenco LL, Donovan C. Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. Blood.
Levin, L. , Held, D. , Fuchs, A. , Citron, M. "O6-Alkylguanine-DNA alkyltransferase.
Travaline JM, Reflections on human suffering. Linacre Q 71:4(271-80)2004 Nov 10988194. Travaline JM, Maurer AH, Charkes ND, Urbain JL, Furukawa S, Criner GJ, Quantitation of regional ventilation during the washout phase of lung scintigraphy: measurement in patients with severe COPD before and after bilateral lung volume reduction surgery. Chest 118:3(721-7)2000 Sep 10750675. Kaur TB, Travaline JM, Gaughan JP, Richie JP Jr, Stellman SD, Lazarus P, Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase.
Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine. Ishiguro K, Shyam K, Penketh PG, et al. Mol. Cancer Ther.