You are at: All > Nucleotides > Nucleotides by Structural Class > Base Modified Deoxynucleoside Triphosphates N-2028 N2-Methyl-2'-deoxyguanosine-5'-Triphosphate N2-Methyl-dGTP Extinction Coefficient: 13,600 Lmol-1cm-1 at 253 nmMolecular Weight: 521.
Evidence that formaldehyde causes cancer in experimental animals infers that it may be a carcinogenic hazard to humans. Formaldehyde reacts with the exocyclic amino group of deoxyguanosine, resulting in the formation of N2-methyl-2'-deoxyguanosine (N2-Me-dG) via reduction of the Schiff base. The same reaction is likely to occur in living cells, because cells contain endogenous reductants such as ascorbic acid and gluthathione.
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