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Using 265 families from the Multiple Autoimmune Disease Genetics Consortium (MADGC), Criswell et al. [35] compared the frequency of ADs in siblings of multiplex families stratified by seven ADs: AITD, RA, MS, SLE, T1D, IBD and PSO. These diseases were pre-specified given a variety of considerations. There was no evidence of familial autoimmunity except in the case of IBD patients in whose families MS was observed among FDRs (OR: 8.