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Although previously considered a passive, degenerative, untreatable disorder of “wear and tear” unrelated to atherosclerosis, recent findings now show that valvular calcification is regulated in a manner similar to that of atherosclerotic calcification and promoted by the systemic, inflammatory milieu characteristic of metabolic syndrome and type 2 diabetes; the molecular “fingerprints” of activated Wnt signaling identified in diabetic medial artery calcification.
Lehto S, Niskanen L, Suhonen M, et al. : Medial artery calcification: a neglected harbinger of cardiovascular complications in non-insulin dependent diabetes mellitus. Arterioscler Thromb Vasc Biol 1996, 16:978-83. PubMed Abstract | Publisher Full Text.