This definition appears rarely
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In 30 cases (63%), downstaging was observed. Among the 46 patients who underwent subsequent surgical therapy, the bladder could be preserved in 26 cases by transurethral resection or segmental resection. According to the criteria of the Japanese Association of Cancer Therapy, a histological effect of GIII or better was obtained in 15 cases (29%). The histological effect correlated well with the tumor-regression rate. As compared with intravenous therapy with MTX, vinblastine, ADM, and CDDP.
Fig 1. MVAC and HD-MVAC regimens. ADM, doxorubicin; CDDP, cisplatin; MTX, methotrexate; VLB, vinblastine.