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In general, as a number of specific allergens in D. pteronyssinus are homologous with other allergens, varying degrees of cross-reactivity can be expected. For example, a high homology of between 48 and 54% occurs between Blo t 3 and the Group 3 allergens from House dust mites, and this results in cross-reactivity between Blomia tropicalis and D. pteronyssinus (68). Der p 4 and Eur m 4 were calculated to be 90% identical, and were also calculated to be approximately 50% identical to insect and mammalian alpha-amylases (25).
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