What does L-VGCC stand for?
L-VGCC stands for L-type voltage-gated Ca(2+) channel
This definition appears rarely
Samples in periodicals archive:
The L-type voltage-gated Ca2+ channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic beta cells. Trus M1, Corkey RF, Nesher R, Richard AM, Deeney JT, Corkey BE, Atlas D.
Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel.
ABSTRACT: L-type voltage-gated Ca2+ channels (Cav1. 2) mediate a major part of insulin secretion from pancreatic â-cells. Cav1. 2, like other voltage-gated Ca2+ channels, is functionally and physically coupled to synaptic proteins. The tight temporal coupling between channel activation and secretion leads to the prediction that rearrangements within the channel can be directly transmitted to the synaptic proteins, subsequently triggering release.
L-type of Voltage-gated Ca2+ Channels (L-type VGCC) is a high voltage-activated channel that exerts spatial and temporal control over cellular calcium concentrations and modulates function such as neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression and neuronal survival. Calcium dependent processes are important in synaptic modification and thus alterations in calcium channel function may be important for both modifying synaptic plasticity and also in age-related neurodegenerative diseases.