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What does L-PIA stand for?

L-PIA stands for L-(-)N6-phenyl-isopropyladenosine


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In addition, a significant reduction occurred in the density of CAl hippocampalpyramidal neurones but not of dentate granule cells with respect to controls. 3InjectionCGS 21680 (5 mg kg-1,significantly prevented the irreversible disappearance of the CAlextracellular electrical somatic responses with respect to controls. In addition, the CAI pyramidalneuronal loss was also prevented. 4The results show that activation of Al adenosine receptorselectrophysiological and morphological correlates of hippocampal neuronal injury after global ischaemiain the gerbil, suggesting that adenosine receptor agonists might have a useful role in the treatment ofneuronal functional and anatomical injury due to ischaemia. Keywords: Gerbil; ischaemia; electrophysiology; L-PIA; hippocampal slicesThe effects of the mixed A1 and A2 adenosine receptor agonist N6-L-phenyl-isopropyladenosine.
Adenosine and its analogue ( - )-N6-R-phenyl-isopropyladenosine modulate anterior pituitary adenylate cyclase activity and prolactin secretion in the rat G. Schettini.
The diastereomers of N6-(4-hydroxyphenyl)isopropyladenosine (HPIA) were synthesized, radioiodinated and used as ligands for adenosine receptors in rat brain membranes. In contrast to the S-isomer, specific binding (measured by displacement with 10 microM N6-R-phenylisopropyladenosine (PIA] of [125I]N6-[R-(3-iodo-4-hydroxyphenyl)isopropyl] adenosine ([125I]R- IHPIA) required about 2 h for equilibrium but bound with a higher affinity.
The effects of the mixed A1 and A2 adenosine receptor agonist N6-L-phenyl-isopropyladenosine (L-PIA) were tested on ischaemia-induced hippocampal neuronal injury in gerbils subjected to 5-min bilateral carotid occlusion. For comparison, the effects of the selective A2 adenosine receptor agonist, CGS 21680 were tested.