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What does III stand for?

III stands for Interferon IFN Induces


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Interferon-alpha- and interferon-gamma-induced.
The type I interferons (IFN) were the first cytokines discovered and named for their potent ability to "interfere" with viral replication 1. In 1957, Isaacs and Lindenmann reported a secreted factor termed "interferon" that could induce a virus-resistant state in chick cells after influenza virus infection 1. The type I IFN family consists of multiple IFN members, single IFN, , , and subtypes, as well as and subtypes found in pig and ovine respectively 2.
[18][19] Viral proteins proven to affect IFN signaling include EBV nuclear antigen 1 (EBNA1) and EBV nuclear antigen 2 (EBNA-2) from Epstein-Barr virus, the large T antigen of Polyomavirus, the E7 protein of Human papillomavirus (HPV), and the B18R protein of vaccinia virus. [19][20] Reducing IFN-a activity may prevent signaling via STAT1, STAT2, or IRF9 (as with JEV infection) or through the JAK-STAT pathway (as with DEN-2 infection). [18] Several poxviruses encode soluble IFN receptor homologs—like the B18R protein of the vaccinia virus—that bind to and prevent IFN interacting with its cellular receptor, impeding communication between this cytokine and its target cells. [20] Some viruses can encode proteins that bind to double-stranded RNA (dsRNA) to prevent the activity of RNA-dependent protein kinases; this is the mechanism reovirus adopts using its sigma 3 (s3) protein, and vaccinia virus employs using the gene product of its E3L gene, p25. [21][22][23] The ability of interferon to induce.