What does H-2b stand for?
H-2b stands for H-2 congenic strains (B10
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Instead, the stepwise combination of each congenic interval showed that the coexpression of these three major loci is necessary and sufficient for the development of fully penetrant disease . The NZM2410 strain is to date the only autoimmune model in which the subset of loci that are necessary and sufficient for disease presentation has been identified. This achievement infused added significance to the identification of the genes corresponding to those three loci. A major obstacle towards the identification of these susceptibility genes has been revealed by the studies of the Sle congenic strains.
25 Mice carrying H2b and H2d haplotypes were more susceptible (LD50 <103 CFU) to a strain of Salmonella Typhimurium of intermediate virulence than those carrying H2a, H2k and H2f haplotypes (LD50 104 CFU). F1 hybrids between H2b (susceptible) and H2f (resistant) showed an intermediate phenotype suggesting a codominant mode of inheritance. Susceptibility of H2b mice was apparent 4 weeks following the infectious challenge and reached a maximum at 7–8 weeks post-inoculation. The bacterial load was 10- to 100-fold higher in the spleen and liver after infection of susceptible H2b congenic strains.
Starting at about three months of age, levels of circulating immune complexes rise greatly in the MRL-lpr/lpr mouse but not the MRL normal (Hewicker 1990). Onset and severity of symptoms associated with the Faslpr gene is strain-dependent. For example, lymphoproliferation varies greatly with congenic strain.