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What does FADA stand for?

FADA stands for Fatty acid dependent agglutinin

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Fatty acid dependent agglutinin (FADA) refers to serum with the special ability to cause agglutination of red blood cells in the presence of certain fatty acids. The agglutinating mechanism is unclear. It has been proposed that the agglutinin reacts with albumin that has been conformationally altered by sodium caprylate and that the immune complex is passively adsorbed onto red blood cells. This report presents data that contradicts the proposal assigning a specific role to albumin in the agglutinating mechanism.
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Abstract. The cell adhesion protein t~-agglutinin is bound to the outer surface of the Saccharomyces cerevisiae cell wall and mediates cell-cell contact in mating, a-Agglutinin is modified by addition of a glycosyl phosphatidylinositol (GPI) anchor as it traverses the secretory pathway. The presence of a GPI anchor is essential for cross-linking into the wall, but the fatty acid and inositol components of the anchor are lost before cell wall association (Lu, C.-E, J. Kurjan, and P. N. Lipke, 1994. A pathway for cell wall anchorage of Saccharomyces cerevisiae a-agglutinin. Mol. Cell. Biol. 14:4825-4833.). Cell wall association of ot-agglutinin was accompanied by an increase in size and a gain in reactivity to antibodies directed against ~l,6-glucan. Several kre mutants, which have defects in synthesis of cell wall/~l,6-glucan, had reduced molecular size of cell wall ot-agglutinin. These findings demonstrate that the cell wall form of oz-agglutinin is covalently associated with/31,6-glucan. The ot-agglutinin biosynthetic precursors did not react with antibody to/~l,6-glucan, and the sizes of these forms were unaffected in kre mutants. A COOHterminal truncated form of a-agglutinin, which is not GPI anchored and is secreted into the medium, did not react with the anti-/31,6-glucan. We propose that extracellular cross-linkage to/31,6-glucan mediates covalent association of a-agglutinin with the cell wall in a manner that is dependent on prior addition of a GPI anchor to ot-agglutinin. T HE cell wall of Saccharomyces cerevisiae consists of two major components:/3 glucans and mannoproteins
Fatty acid dependent agglutinin (FADA) refers to serum with the special ability to cause agglutination of red blood cells in the presence of certain fatty acids. The agglutinating mechanism is unclear. It has been proposed that the agglutinin reacts with albumin that has been conformationallly altered by sodium caprylate and that the immune complex is passively adsorbed onto red blood cells. This report presents data that contradicts the proposal assigning a specific role to albumin in the agglutinating mechanism.