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What does FAB stand for?

FAB stands for Facilitated Allergen Binding

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Inhibition of CD23-dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules. Pree I1, Shamji MH, Kimber I, Valenta R, Durham SR, Niederberger V.
The IgE-facilitated allergen binding (FAB) assay: Validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses Shamji, Mohamed H. ; Wilcock, Louisa K. ; Wachholz, Petra A. ; Dearman, Rebecca J. ; Kimber, Ian; Wurtzen, Peter A.
The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses. Shamji MH1, Wilcock LK, Wachholz PA, Dearman RJ, Kimber I, Wurtzen PA, Larché M, Durham SR, Francis JN.
02; trimer vs. placebo: P<0. 04] but not in the Bet v 1 fragments-treated group. Trimer-treated patients had higher levels of Bet v 1-specific IgG than fragment-treated patients. The degree of inhibitory activity of IgE-facilitated allergen binding correlated with Bet v 1-specific IgG levels following SIT (R=0. 492; P=0. 012).
IgE receptors on the surface of antigen-presenting cells facilitate the presentation of allergens in the presence of specific IgE antibody resulting in T-cell activation. Interference with these IgE-dependent mechanisms by ‘blocking’ IgG antibodies may downregulate T-cell responses and manifest as a reduction in allergic responses in vivo. The vigor of proliferative responses by T-cell clones is representative of the binding of allergen-IgE complexes to B cells. Therefore, a simplified assay can be employed that measures the binding of allergen-IgE complexes to B cells instead of a more complex assay involving proliferative assays using antigen-specific T-cell clones. Allergen-IgE complexes can be easily detected by flow cytometry and this simplified technique is called the IgE-facilitated allergen binding.
Validation of a Functional Assay of IgE-Facilitated CD23-Dependent Allergen Binding to B Cells to Monitor Clinical Effica Presented at: 2006 AAAAI Annual Meeting Miami, FL, March 3-7, 2006 Shamji MH, Wilcock LK, Larché M, Francis JN, Durham SR Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, UK Rationale:‘Blocking’ IgG antibodies induced by allergen immunotherapy can inhibit IgE-facilitated allergen binding.
Validation of a Functional Assay of IgE-Facilitated CD23-Dependent Allergen Binding to B Cells to Monitor Clinical Effica Presented at: 2006 AAAAI Annual Meeting Miami, FL, March 3-7, 2006 Shamji MH, Wilcock LK, Larché M, Francis JN, Durham SR Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, UK Rationale:‘Blocking’ IgG antibodies induced by allergen immunotherapy can inhibit IgE-facilitated allergen binding.