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Delta opioid peptide [D-Ala2,D-leu5]enkephalin blocks the long-term loss of dopamine transporters induced by multiple administrations of methamphetamine: involvement of opioid receptors and reactive oxygen species. Tsao, L. I. , et al. J. Pharmacol.
Chronic treatment of neuroblastoma x glioma NG108-15 hybrid cells with the opioid agonist D-Ala,2 D-Leu5-enkephalin (DADLE) induces a homologous desensitization of the delta opioid receptors present in these cells. Since the Kd value of the delta opioid receptor's high-affinity state reflects the potency of the agonist, we examined the effect of receptor desensitization in NG108-15 cells on the percentage of receptor in the high-affinity state.
[D-Ala2, D-Leu5]-Enkephalin | DADLE 4115-v 0. 5 mg | 25. 00 EUR Tyr-D-Ala-Gly-Phe-D-Leu.
The purpose of the present study was to determine if delta-opioid agonists could inhibit proinflammatory cytokine production by macrophages. Murine macrophages (RAW 264. 7) were pretreated for 4 h with media, a dose range (10(-4) to 10(-7) M) of DADLE ([D-Ala2], D-Leu5]-enkephalin.
Peptide Institute, Inc. is a global supplier of [D-Ala2,D-Leu5]-Enkephalin from Japan. Name:[D-Ala2,D-Leu5]-Enkephalin, Code:4115-v,
[Show abstract] [Hide abstract] ABSTRACT: It has been demonstrated that [D-Ala2, D-Leu5] enkephalin (DADLE), a delta opioid agonist, protected neuron from hypoxic neuronal injury by activating the delta opioid receptor (DOR). However, whether DADLE can prevent neuronal injury induced by severe hypoxia like oxygen-glucose deprivation (OGD) is not clear. Here, we investigated whether DADLE has a protective effect against neuronal injury induced by oxygen-glucose deprivation.