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What does D-P stand for?

D-P stands for DNA-protein cross-links


This definition appears rarely

Samples in periodicals archive:

On the other hand, X-irradiation produced little if any crosslinking (see below) (Smith, 1962). Since these early studies, photoinduced DNA-protein crosslinking has been observed in other cellular systems, as well as in isolated DNA-protein complexes. Among the latter are the crosslinking of histones to DNA in eukaryotic nucleosomes, the crosslinking of RNA polymerase and DNA polymerases to DNA, and the cross-linking of the gene 5 "melting" protein from fd phage to single-stranded DNA. (For reviews and references, see Smith, 1976; Shetlar, 1980; Saito and Sugiyama, 1990). Detecting DNA-Protein Crosslinks A number of methods have been developed for detecting DNA-protein cross-links.
Therefore, measurement of malondialdehyde is widely used as an indicator of lipid peroxidation (1). Increased levels of lipid peroxidation products have been associated with a variety of chronic diseases in both humans (2, 3) and model systems (4, 5). MDA reacts readily with amino groups on proteins and other biomolecules to form a variety of adducts (1), including cross-linked products (6). MDA also forms adducts with DNA bases that are mutagenic (7, 8) and possibly carcinogenic (9). DNA-protein cross-links.
The results were the first high-resolution structure of a multisubunit cellular RNA polymerase. The lab then tracked the path of the transcript RNA and the template DNA through the polymerase structure using RNA-protein and DNA-protein cross-links.
DNA damage caused by oxygen-derived species including free radicals is the most frequent type encountered by aerobic cells. When this type of damage occurs to DNA, it is called oxidative DNA damage and it can produce a multiplicity of modifications in DNA including base and sugar lesions, strand breaks, DNA-protein cross-links and base-free sites. Accurate measurement of these modifications is essential for understanding of mechanisms of oxidative DNA damage and its biological effects.
RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links.
RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links.