This definition appears rarely
Samples in periodicals archive:
Title: Meta-analysis shows dopamine receptor D1 gene.
Catalano M, Nobile M, Novelli E, Nöthen MM, Smeraldi E (Oct 1993). "Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients". Biological Psychiatry 34 (7): 459–64. doi:10. 1016/0006-3223(93)90236-7. PMID 8268330.
For example, in the initial report (Ebstein et al. 1996) four personality traits were compared in both the 7 alleles present/absent group and the 4,4 and 4,7 genotype groups, making a total of eight tests. No correction of multiple tests was performed, because it was stated that there was an a priori hypothesis. However the hypothesis was related to the possible role of the dopaminergic system in NS ( Cloninger 1987), but did not point to any specific gene from this system, nor to any particular polymorphism or allele. In 1987, no dopamine receptor genes.
Ebstein 1 first highlighted the saga of an 'adventure gene': the dopamine D4 receptor gene (DRD4) and its association with substance abuse and personality. This was followed with a report by Baron 2 who suggested that this saga is sagging due to conflicting reports emerging. It now appears that the saga continues with 'severity of dependence' to substance abuse, another variable that may be pertinent to the DRD4 association.
Arinami T, Gao M, Hamaguchi H, Toru M (April 1997). "A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia". Hum. Mol. Genet. 6 (4): 577–82. doi:10.
Title: Role of nicotine dependence in the association between the dopamine receptor gene.
Although the human genome contains five dopamine receptor genes, the number of dopamine receptor mRNA species that it encodes is higher. This results from the fact that polymorphism and alternative splicing events play a role in dopamine receptor gene expression and leads to the existence of more than five different receptor binding sites.