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What does CAN stand for?

CAN stands for Cardiovascular autonomic neuropathy


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Figure 2. Relative risks and 95% confidence intervals for association between cardiovascular autonomic neuropathy.
However, as far as we known, no study demonstrated the association of PAD with CAN. The EURODIAB data showed an association of low HDL cholesterol and high triglycerides in patients with cardiovascular autonomic neuropathy, suggesting a role for an adverse lipid profile in the pathogenesis of CAN [25]. Autonomic neuropathy was already related to lower-extremity arterial calcification in type 1 diabetes [3].
Neurovascular dysfunction resulting from DAN contributes to a wide spectrum of clinical disorders including erectile dysfunction, loss of skin integrity, and abnormal vascular reflexes. Disruption of microvascular skin blood flow and sudomotor function may be among the earliest manifestations of DAN and lead to dry skin, loss of sweating, and the development of fissures and cracks that allow microorganisms to enter. These changes ultimately contribute to the development of ulcers, gangrene, and limb loss. Various aspects of neurovascular function can be evaluated with specialized tests, but generally these have not been well standardized and have limited clinical utility. Cardiovascular autonomic neuropathy.
Diabetic cardiovascular autonomic neuropathy (CAN) is one of several common diabetic microvascular complications. CAN involves autonomic nerve fibers innervating the heart and blood vessels, and consequentially represents a significant cause of cardiovascular morbidity and mortality in diabetic patients [1]. A growing body of clinical and laboratory evidence suggests that glycemic variability (GV) may play a role in developing autonomic neuropathy independently of chronic hyperglycemia, by contributing to oxidative stress that leads to neural damage [2], [3].