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1990; Itoh et al. 1996; Osamura et al. 1997). Without postfixation by osmic acid, these embedding media also can preserve ultrastucture adequately and satisfactorily. We have had satisfactory results for both ultrastucture and antigenicity in localizing large molecules such as IgA, carcinoembryonic antigen (CEA), and peptides. Although it has been claimed that conventional embedding, such as epoxy resin, can preserve antigenicity only in secretory granules, LR White and Lowycril can demonstrate a variety of substances with larger molecular size on various cell organelles such as the rough endoplasmic reticula, Golgi saccules, and secretory granules, and on secretory vesicles (Itoh et al.