This definition appears rarely
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1A shows part of the proximal region of the human glucose-6-phosphatase gene. As indicated, two CRE-like sequences are present, resembling the canonical CRE sequence 5'-TGACGTCA-3'. The distal CRE-like site (CRE1) and the proximal CRE-like site (CRE2) differ on two or three positions, respectively, in comparison to the canonical CRE. To investigate the biological function of these elements we constructed a battery of reporter plasmids containing both CRE-like elements.
Computational analysis identified two putative CRE-like elements, spanning −528 to −340 (a) and −1895 to −1723 (A) in the MAP1LC3B promoter. CHOP, a known target of ATF4, also has those cis-acting elements (site b and site B) in its promoter ( Figure 5a). ChIP assays demonstrated that ATF4 indeed bound to the cis-acting elements within the MAP1LC3B and CHOP promoters in NB4 cells (.