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7 mg/ml, and more than 1 mg/ml was required to obtain a complete inhibition. We also analyzed the effect of SPS on the incorporation and binding of other key components of the complement system. Using a fixed SPS concentration of 0. 5 mg/ml (within the concentration window, where the LP remains unaffected) we analyzed the incorporation or binding of C1q, C4, C3, and C9 for the classical pathway; properdin, C3, and C9 for the alternative pathway; and MBL, C4, and C3 for the lectin pathway as a function of the serial serum-SPS dilutions. Various complement-deficient sera.