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It is therefore prudent to consider the two categories of patients separately. On the basis of published data, the CDR in MPD patients is flanked by D20S206 and D20S481 and the CDR in MDS/AML patients is flanked by D20S465 and D20S481 (Bench et al. , 1998a; Wang et al. , 1998). Two yeast artificial chromosome (YAC) contigs which span these CDRs have been constructed (Bench et al. , 1998a; Stoffel et al.
Institute of Human Genetics and Anthropology, University of Freiburg, Germany. For a long time, the evolutionary relationship between human and African apes, the 'trichotomy problem', has been debated with strong differences in opinion and interpretation. Statistical analyses of different molecular DNA data sets have been carried out and have primarily supported a Homo-Pan clade. An alternative way to address this question is by the comparison of evolutionarily relevant chromosomal breakpoints. Here, we made use of a P1-derived artificial chromosome (PAC)/bacterial artificial chromosome (BAC) contig.