Safety and Efficacy Study of Iodine-131 Anti-B1 Antibody for Chronic Lymphocytic Leukemia
The recruitment status of this study is unknown because the information has not been verified recently.
[Show abstract] [Hide abstract] ABSTRACT: A patient with chronic lymphocytic leukemia developed Ph1-positive chronic myelocytic leukemia after a 6-yr course of CLL. Chemotherapy for CLL consisted of chlorambucil and steroids, later vincristine and bleomycin; after resistance to these agents, cyclophosphamide, vincristine and prednisolone were applied. When CML was diagnosed, we found two morphologically distinct populations of malignant cells in the bone marrow; the Ph1-chromosome was identified, and immunological surface marker studies also demonstrated two distinct malignant cell populations.
B-cell chronic lymphocytic leukemia: Introduction B-cell chronic lymphocytic leukemia: A slow progressing disease involving cancerous B-cell lymphocytes which take over the healthy cells in the lymph nodes. B-cells help the body to fight infections so when the disease becomes more advanced, the body is less able to fight infection as there are fewer healthy, functioning B-cells. More detailed information about the symptoms, causes, and treatments of B-cell chronic lymphocytic leukemia is available below.