3 points (SD 3. 1, range 7–22). A high global risk (10-year risk >20%) of coronary, cerebrovascular, and peripheral arterial disease and heart failure  would be reflected in a score >17 points for women and >14 points for men. There were 15 patients with this high-risk profile among study participants. In our primary hippocampal region of interest (CA23DG), average cortical thickness.