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Our personal experience with this antibody has suggested that it is a highly sensitive wide-spectrum cytokeratin antibody, equalling or surpassing the sensitivity of more widely utilized markers, such as the AE1/AE3 cocktail (Andrew L Folpe and Allen M Gown, personal observations). In normal tissues, OSCAR appears to recognize all cytokeratin-positive cells, with the exception of the superficial layers of the epidermis (most likely reflecting non-reactivity with high molecular weight cytokeratins 1 and 10). Monoclonal antibody Cam5. 2 recognizes the low molecular weight cytokeratins 8 and 18 (and possibly 19). We chose to use these two antibodies in this study to maximize the possibility of detecting anomalous cytokeratin expression.