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6 Antimetabolites and inactivation Antagonists may compete for reaction sites of the apoenzyme or may react with pyridoxal phosphate to form inactive compounds. Deoxypyridoxine is a potent pyridoxine antagonist because of competition for apoenzyme sites but is a useful agent to accelerate pyridoxine deficiency in experimental animals. This same compound inhibits tyrosine decarboxylase. Methoxypyridoxine is another antagonist. Oxopyrimidine (2-methyl-4-amino-5-hydroxymethyl-pyrimidine.
In another embodiment, the 2-aminobenzyl alcohol is part of a heterocyclic system. Preferred examples include but are not limited to 2-amino-3-(hydroxymethyl)-pyridine, 3-amino-4-(hydroxymethyl)pyridine, 4-amino-5-(hydroxymethyl)-pyrimidine.