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What does T2S stand for?

T2S stands for 3,3'-T2 sulfate


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In addition to deiodination, iodothyronines are metabolized by conjugation of the phenolic hydroxyl group with sulfate or glucuronic acid (Fig. 1) (15, 16). Sulfation and glucuronidation are so-called phase II detoxification reactions, the general purpose of which is to increase the water-solubility of the substrates and, thus, to facilitate their biliary and/or urinary clearance. However, iodothyronine sulfate levels are normally very low in plasma, bile and urine, because these conjugates are rapidly degraded by D1, suggesting that sulfate conjugation is a primary step leading to the irreversible inactivation of thyroid hormone (17, 18).
Examples of drugs acting principally through the former mechanism are diphenylhydantoin and phenobarbital,247-249 and via the latter, colestipol237, ferrous sulfate238a, aluminum hydroxide238b and sucralfate238c. Patients receiving these drugs should increase the secretion of hormone from the thyroid gland in order to compensate for the enhanced hormonal loss through degradation or fecal excretion.