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Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain. Calvo R, Obregón MJ, Ruiz de Oña C, et al. J. Clin. Invest.
L-3,3',5-Triiodothyronine, Free Acid is one of the hormones produced by the thyroid gland. L-3,3',5-Triiodothyronine, Free Acid is also produced in peripheral tissues as the active metabolite of Thyroxine. The compound is shown to be involved in the maintenance of metabolic homeostasis.
3,3′,5-Triiodo-L-thyronin e also referred to as O-(4-Hydroxy-3-iodophenyl )-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function. 3 The product also positively regulates the hepatic FGF21 expression2 and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.
Thyroxine (T4), 3,3',5'-tri-iodothyronine (reverse T3; rT3) and di-iodothyronines (3,3'-T2 and 3',5'-T2) were measured in pig amniotic fluid (AF) and allantoic fluid (Al) between 32 and 113 days of normal pregnancy. Low but measurable quantities of T4 in AF and Al (2·1 ± 0·3 and 3·2 ±0·5 nmol/l respectively) were found before the onset of fetal thyroid gland function, which indicates the maternal source of T4.
Amniotic fluid concentrations of 3,3′,5′-tri-iodothyronine (rT3), 3,3′-di-iodothyronine (3,3′-T2), 3,5,3′-tri-iodothyronine (T3) and T4 were studied in 384 women during normal and complicated pregnancy. An inverse correlation was observed between decreasing rT3 and increasing 3,3′-T2 concentrations in amniotic fluid with gestational age. The mean rT3 level in normal pregnancy was 2.