What does AA861 stand for?

Both 2,3,5-trimethyl-6-(12-hydroxy-5, 10-dodecadiynyl)-l, 4-benzoquinone (AA861) and 3, 4, 2‘, 4’-tetrahydroxychalcone inhibited 12-lipoxygenase of mouse epidermis. The IC50 of AA861 and 3, 4, 2‘, 4’-tetrahydroxychalcone for epidermal 12-lipoxygenase were 1. 9 and 0. 2 µM, respectively. These agents showed very weak inhibitory actions on epidermal cyclooxygenase, with the potency of inhibition for cydooxy-genase less than 1/50 of that for lipoxygenase.

Anterior pituitary cells from female rats cultured with arachidonic acid released β-end-IR in a dose- and time-dependent manner. To determine which metabolites of arachidonic acid stimulated the release of β-end-IR, we examined the effects of an inhibitor of the cyclooxygenase, indomethacin, and an inhibitor of the 5-lipoxygenase, 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone.