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What does FMT stand for?

FMT stands for 18)F]6-fluoro-l-m-tyrosine

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Although positron emission tomography (PET) and the aromatic L-amino acid decarboxylase (AADC) tracer 6-[18F]fluoro-L-m-tyrosine (FMT) has been used to assess the integrity of the presynaptic dopamine system in the brain, relatively little has been published in terms of brain FMT uptake values especially for normal human subjects. Twelve normal volunteer subjects were scanned using PET and FMT to determine the range of normal striatal uptake values using Patlak graphical analysis.
The tracer 6-[18F]fluoro-l-m-tyrosine (FMT) was studied with regard to its biochemistry and kinetics, as well as its utility in evaluating brain dopaminergic function in primates before and after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment using positron emission tomography (PET). Plasma analysis of FMT and its F18-labeled metabolites 6-fluoro-3-hydroxyphenylacetic acid (FPAC) and 6-fluoro-3-hydroxyphenylethylamine (FMA) during PET scanning enabled kinetic analysis of FMT uptake.
6-[18F]Fluoro-L-dopa was synthesized as previously described (Namavari et al. , 1992). 6-[18F]Fluoro-L-m-tyrosine synthesis was as follows: [18F]F2 gas was prepared as described by Roberts et al. (1995). L-m-Tyrosine (36. 2 mg; 200 μmol) was placed in a glass reaction vessel (2 × 10 cm) and dissolved in 12 mL of 1:1 trifluoroacetic acid and glacial acetic acid ( DeJesus et al.
In idiopathic Parkinson's disease (PD) the clinical features are heterogeneous and include different predominant symptoms. The aim of the present study was to determine the relationship between subregional aromatic l-amino acid decarboxylase (AADC) activity in the striatum and the cardinal motor symptoms of PD using high-resolution positron emission tomography (PET) with an AADC tracer, 6-[18F]fluoro-ʟ-m-tyrosine (FMT).
Jordan, S. , Eberling, J. L. , Bankiewicz, K. S. , Rosenberg, D. , Coxson, P. G. , VanBrocklin, H. F. , O'Neil, J. P. , and Jagust, W. J. 1997. 6-[18F]fluoro-L-m-tyrosine: metabolism and positron emission tomography kinetics, and 1-methyl-4-phenyly-1,2,3,6-tetrahydropyridine lesions in primates. Brain. Res. 750:264-276.
Although positron emission tomography (PET) and the aromatic L-amino acid decarboxylase (AADC) tracer 6-[18F]fluoro-L-m-tyrosine (FMT) has been used to assess the integrity of the presynaptic dopamine system in the brain, relatively little has been published in terms of brain FMT uptake values especially for normal human subjects. Twelve normal volunteer subjects were scanned using PET and FMT to determine the range of normal striatal uptake values using Patlak graphical analysis.