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11-Deoxycorticosterone (DOC), or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, as well as desoxycortone (INN), deoxycortone (BAN), and cortexone, is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. It has no significant glucocorticoid activity.  As its names indicate, 11-deoxycorticosterone can be understood as the 21-hydroxy- variant of progesterone or as the 11-deoxy- variant of corticosterone.
Test ID DCRN 11-Deoxycorticosterone, Serum Useful For Diagnosis of suspected 11-hydroxylase deficiency, including the differential diagnosis of 11 beta-hydroxylase 1 (CYP11B1) versus 11 beta-hydroxylase 2 (CYP11B2) deficiency, and in the diagnosis of glucocorticoid responsive hyperaldosteronism.
Using the radiolabeled precursors of adrenal steroids 14C-11-deoxycorticosterone (DOC) and 14C-progesterone (14C-PROG) we demonstrate that rat skin can synthesize a number of steroids. TLC separation of labeled metabolites show that among the 14C-steroid products, two co-migrate with corticosterone (B) and 11-dehydrocorticosterone (A) standards. Thus, normal rodent skin possesses steroidogenic activity that can be shown using progesterone or DOC as primary substrates.
Substance record SID 56412749 for [4-14C]-11-deoxycorticosterone submitted by BindingDB.
Deoxycorticosterone - Moravek Biochemicals carbon 14 and tritium labeled compounds
In parallel studies, metyrapone (1. 0 mm) depressed the formation of both 11-oxy and 11-deoxymetabolies from [4-14C] cholesterol, overall inhibition ranging from 66 to 86%. The conversion of [4-14C] 11-deoxycorticosterone to corticosterone was inhibited by 93 % under identical conditions. Metyrapone did not, however, impair the overall transformation of either [4-14C]pregnenolone or [4-14C]progesterone, since the inhibition of cortisol and corticosterone biosynthesis was associated with an increment in 11-deoxycortisol (with [4-14C] pregnenolone) or 11-deoxycorticosterone (with [4-14C]progesterone).