What does OAG stand for?
OAG stands for 1,2-oleoyl acetylglycerol
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7-8 In con-trast, roles for diacylglycerol and protein kinase C inlacrimal gland protein secretion have not been dem-onstrated. The tumor-promoting phorbol esters can induceprotein secretion from many cell types. 9 Phorbolesters stimulate secretion by mimicking the effect ofdiacylglycerol to bind and activate protein kinase C. Phorbol esters can thus be used to study the role ofprotein kinase C in cellular responses, including se-cretion. In the present study we determined whether acti-vating protein kinase C with phorbol esters or withthe diacylglycerol analog 1,2-oleoyl acetylglycerol.
To identify a role for protein kinase C in lacrimal gland protein secretion, we incubated rat exorbital lacrimal gland acini in the ester 4-beta-phorbol 12, 13 dibutyrate (beta-phorbol dibutyrate), its inactive isomer 4-alpha-phorbol 12, 13 dibutyrate (alpha-phorbol dibutyrate), and the diacylglycerol analog 1,2-oleoyl acetylglycerol (OAG). We determined protein secretion by measuring the activity of peroxidase, a protein secreted by lacrimal gland acini.
A progressive decrease in the fraction of cells respondingafter: 1) incubationin PTX for 30, 50 or 70 min at 37 OC, or 2) incubation in PTX for 4 hr at 5,23 or 37 OC. These changes were paralleled by a progressive decrease in the magnitude of theresponse to NA. The actions of PTX suggest that transmitter responses are mediated by a G-proteinsimilar in stucture to Ni (Gilman, Cell 36 577, 1984). Studies of DRG cells voltage clamped andinternally dialyzed with guanosine 5'-O-[2-thiodiphosphate]The 10 uM NA-induced decrease in voltage-dependent calcium current was blocked by GDP-S -S (100-500uM) in a dose-dependent fashion. The actions of PTX and GDP-8 -S are specific for receptor-mediatedinhibition of calcium channels:neither blocks the decrease in APD or calcium current in responseto 60 uM 1,2-oleoyl acetylglycerol.
Rane SG, Dunlap K (1986) Kinase C activator 1,2 oleoyl acetylglycerol.