This definition appears rarely
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Although platinum-based chemotherapy is currently standard of care in NSCLC, data suggest that certain individual tumors may have inherent resistance to platinum compounds. Excision repair cross-complementation group.
Zhou W, Gurubhagavatula S, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Su L, Christiani DC: Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res 2004, 10:4939-43. PubMed Abstract | Publisher Full Text.
Xeroderma Pigmentosum (XP) is a disorder caused by deficiency of genes involved in NER. Cells derived from XP patients are exquisitely sensitive to cisplatin . In addition, the favorable response of testicular cancer to cisplatin was associated with low levels of XP complementation group A (XPA) and excision repair cross-complementation group.
Bohanes P, Labonte MJ, Lenz HJ (Sep 2011). "A review of excision repair cross-complementation group 1 in colorectal cancer". Clinical Colorectal Cancer 10 (3): 157–64. doi:10. 1016/j. clcc. 2011.
Both ends of the break are first bound by the Ku70/Ku80 heterodimer, which then recruits the catalytic subunit of the DNA dependent protein kinase (DNA-PKcs) . If necessary, the ends can be trimmed by nucleases (such as Artemis) or filled in by DNA polymerases (such as Polµ or Pol?) to create compatible ends . Finally, the ligation complex, consisting of DNA ligase IV, X-ray cross-complementation group.