What does S-M stand for?
S-M stands for serosal-to-mucosal
This definition appears rarely
Samples in periodicals archive:
MRP activity, as shown by the efflux clearance of 5-CF in the serosal to mucosal direction, was reduced to 50 ±7% of the control values (p = 0. 08) in the LPS-treated animals (Fig. 4). Adding the MRP-specific inhibitor MK571 to intestinal segments isolated from the control rats reduced the efflux to 37±14% (Fig. 4). In contrast, the addition of the inhibitor to the mucosal side of segments isolated from the LPS-treated rats tended to decrease 5-CF efflux, although the differences failed to reach the 5% level of statistical significance (0.
These results are in agreement with those obtained in the previous study in the brush-border membrane vesicles. On the other hand, in the absence of an H+-gradient, the S-to-M transport of ceftibuten was proven to be significantly higher than the M-to-S one. In addition, either ATP-depletion of the mucosa or the addition of probenecid proved to enhance significantly the permeability of ceftibuten. These findings suggest the existence of an active secretory transport system for ceftibuten in the jejunal mucosa. To estimate potential effects of glycerol esters on efflux pumps as well as peptide transporters, the mucosal-to-serosal (M-to-S) and serosal-to-mucosal.
Diquafosol sodium exhibits a P2Y2 agonist activity that accelerates fluid transport from the serosal to mucosal (tear) side via chloride channel activation after intracellular calcium ion concentration elevation in the conjunctival epithelium. 23, 24 This action has been demonstrated in normal rat, 10 rabbit, 11 and cat 12 experimental models in which the Schirmer test value and tear meniscus area increased after topical application of the diquafosol ophthalmic solution.
A number of metabolites such as phenolics, flavonoid, carotenoid, terpenoid and triterpene have been found in this fruit. Extracts and metabolites of this plant, particularly those from the leaves and fruit, possess useful pharmacological activities . There is only one report about the effect of guava extracts on drug transport: guava extract showed a potent inhibitory effect on P-gp mediated efflux in Caco-2 cells. It was also found to inhibit efflux transport from serosal to mucosal.