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5 to 10 microg/100 g BW) on serum TSH and GH levels in rats made hypothyroid by propylthiouracil and iopanoic acid administration. In such animals deiodinase activities were inhibited and thyroid hormones serum levels strongly reduced. The effects of T2s were compared with those elicited by 3,5,3'-triiodo-L-thyronine (T3) (2. 5 microg/100 g BW). The serum TSH level was much greater in hypothyroid rats than in euthyroid ones.
Human platelet aggregation and degranulation is induced in vitro by L-thyroxine, but not by 3,5,3'-triiodo-L-thyronine or diiodothyropropionic acid (DITPA). Mousa SS, Davis FB, Davis PJ, et al. Clin. Appl. Thromb. Hemost.
7. Dudley SC, Baumgarten CM. Bursting of cardiac sodium channels after acute exposure to 3,5,3_-triiodo-L-thyronine. Circ Res. 1993;73:301–313.
7)R. Horiuchi, K. Yamauchi, H. Hayashi, S. Koya, Y. Takeuchi and K. Kato, "Purification and Characterization of 55-kDa Proteinwith 3,5,3'-Triiodo-L-thyronine.
The L-triiodothyronine (T3, liothyronine) thyroid hormone is normally synthesized and secreted by the thyroid gland in much smaller quantities than L-tetraiodothyronine (T4, levothyroxine, L-thyroxine). Most T3 is derived from peripheral monodeiodination of T4 at the 5 position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.